Coversyl Plus Contraindications

Linked to perindopril: Hypersensitivity to the active substance or to any other ACE inhibitor; History of angioedema (Quincke's edema) associated with previous ACE inhibitor therapy; Hereditary/idiopathic angioedema; Second and third trimesters of pregnancy; Concomitant use of Perindopril arginine + Indapamide (Coversyl Plus) with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m²); Concomitant use with sacubitril/valsartan; Extracorporeal treatments leading to contact of blood with negatively charged surfaces; Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney.
Linked to indapamide: Hypersensitivity to the active substance or to any other sulphonamides; Hepatic encephalopathy; Severe hepatic impairment; Hypokalemia; As a general rule, this medicine is inadvisable in combination with non antiarrhythmic agents causing torsades de pointes; Lactation.
5 mg/1.25 mg: Severe renal impairment (creatinine clearance below 30 ml/min).
10 mg/2.5 mg: Severe and moderate renal impairment (creatinine clearance below 60 ml/min).
Linked to Perindopril arginine + Indapamide (Coversyl Plus): Hypersensitivity to any of the excipients.
Due to the lack of sufficient therapeutic experience, Perindopril arginine + Indapamide (Coversyl Plus) should not be used in: Dialysis patients; Patients with untreated decompensated heart failure.